Pilot Study of Olanzapine and Aprepitant to Prevent Nausea and Vomiting in Children Receiving Chemotherapy
Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the feasibility of a larger trial comparing
olanzapine and aprepitant and to obtain preliminary data on the effectiveness of these two
medications to treat nausea and vomiting in children receiving chemotherapy. Children
receiving 2 cycles of chemotherapy with a high risk of causing nausea and vomiting will
receive olanzapine in one cycle and aprepitant in another cycle. Children will be randomized
to see which medicine they receive first. The investigators will record the number of extra
medications used for nausea, the number of times a child vomits, and the amount of nausea the
child feels each day.