Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer
cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies,
such as rituximab, can block cancer growth in different ways. Some block the ability of
cancer cells to grow and spread. Others find cancer cells and help kill them or carry
cancer-killing substances to them. Radiation therapy uses high-energy x-rays to kill cancer
cells. Motexafin gadolinium may make cancer cells more sensitive to radiation therapy and
combination chemotherapy. Giving motexafin gadolinium together with chemotherapy, rituximab,
and radiation therapy may kill more cancer cells.
PURPOSE: This phase II trial is studying the side effects of giving motexafin gadolinium
together with combination chemotherapy, rituximab, and whole-brain radiation therapy and to
see how well it works in treating patients with newly diagnosed primary central nervous
system lymphoma.