Pilot Study of Intra-Arterial Cisplatin With IV Thiosulfate in Patients With Lung Cancer or Lung Metastases
Status:
Completed
Trial end date:
2013-05-17
Target enrollment:
Participant gender:
Summary
This phase I study proposes the use of systemic thiosulfate rescue to allow supradose
intra-arterial cisplatin delivery to lung tumors. Eligible patients would be those with at
least one lung lesion large enough of characterize angiographically. All patients will first
undergo a CT arteriogram of the target tumor. Patients will then receive 2 treatments on 2
consecutive weeks. The primary endpoint will be toxicity, with secondary endpoint of response
as measured on week 4. This pilot study will also determine how technically feasible it is to
locate the blood supply to these tumors and deliver cisplatin.
If the first 6 patients do well, 6 additional patients will be accrued for a total of 12.