Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

• Status: NOT_YET_RECRUITING
• Trial end date: 2032-09-01

Summary

Pilot study to determine feasibility of adding intrathecal chemotherapy and maintenance therapy after high dose chemotherapy for treatment of newly diagnosed HR-EBTs in patients less than 6 years of age.

• Phase: EARLY_PHASE1

Details

• Lead Sponsor: C17 Council
• Treatments: Carboplatin; Celecoxib; Cisplatin; Cyclophosphamide; Etoposide; etoposide phosphate; Filgrastim; Granulocyte Colony-Stimulating Factor; Hydrocortisone; Isotretinoin; Mesna; Tamoxifen; Temozolomide; Thiotepa; Vincristine