Diflunisal is an anti-inflammatory drug (like ASA or ibuprofen) that has been used as a
painkiller for 20 years. Recent research shows that it may have an anti-HIV effect in the
laboratory. Approximately 20 HIV-infected adults who are not receiving antiretroviral therapy
will be given diflunisal by mouth twice daily for 4 weeks, at a dose that has been shown to
be safe when used to treat pain. Subjects will be monitored closely for safety and will have
frequent blood tests during the study to see if the drug has any effect on the level of HIV
in their blood.