Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty
Status:
Completed
Trial end date:
2013-02-01
Target enrollment:
Participant gender:
Summary
This is a prospective, randomized study from pre-surgery to 6 weeks post-surgery designed to
detect changes in coagulability following elective total knee and hip arthroplasty. Patients
will be randomized to one of the two standard prophylaxis treatments used at Sinai Hospital:
1. Arixtra (2.5 mg SQ/QD) subcutaneous injection daily for 2 weeks followed by aspirin 325
mg for 5 weeks, or
2. Pneumatic compression stockings (MCS, Active Care, medical compression systems Inc.,
Israel) for 2 weeks with concomitant Aspirin 325 mg daily for 5 weeks.