Pilot RCT Local Gentamicin for Open Tibial Fractures in Tanzania
Status:
Active, not recruiting
Trial end date:
2023-11-01
Target enrollment:
Participant gender:
Summary
Local application of antibiotics directly to the traumatic wound is a promising strategy for
the prevention of infection after open tibia fractures, which are a significant source of
disease burden globally, particularly in low-income countries. This pilot study aims to
assess feasibility of a randomized controlled trial to measure the effect of locally applied
gentamicin on risk of infection for open tibial fractures in Tanzania. If proven effective,
local gentamicin would be a highly cost-effective strategy to reduce complications and
disability from open tibial fractures that could impact care in both high- and low-income
countries.