Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas
Status:
Terminated
Trial end date:
2017-12-19
Target enrollment:
Participant gender:
Summary
This study will be aimed at investigating the effectiveness of a treatment for brain tumors
called Photodynamic Therapy, or PDT. Briefly, a subject will receive a light-sensitive drug,
called Photofrin®, the day before a tumor removal surgery. The next day, after the tumor is
removed, red light from a laser will be shone into the tumor cavity through a light-diffusing
sphere. This light will activate the photosensitizer, and possibly kill any tumor cells that
may be left.
We plan to measure how long the subject may go without a new tumor regrowth, and overall how
long subjects survive. We will compare these results to typical results to see if we are
seeing any improvements.
Objective: To define the antitumor activity of Photofrin® and laser light activation within
the confines of a Phase II study.