Photodynamic Therapy Compared to Adapalene 0.1% Gel Plus Doxycycline in the Treatment of Acne Vulgaris
Status:
Completed
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
- Acne vulgaris is a common inflammatory skin disease that affects more than 85% of teens
and some people may continue throughout adulthood.
- Topical retinoids related to oral antibiotics are considered first-line treatment of
moderate inflammatory acne.
- Recently, photodynamic therapy (PDT) with a photosensitizer, 5-aminolevulinic acid (ALA)
or methyl aminolevulinate (MAL), has proven useful in the management of inflammatory
acne. Although progress has been made in the study of photodynamic therapy for acne, to
date, no study has compared PDT with standard and well-validated pharmaceutical
treatments and with the current recommended therapy for most types of acne combination
therapy with a topical retinoid plus one or more antimicrobial agents.
Hypothesis
- PDT with the photosensitizer ALA will be effective and safe for the treatment of
moderate facial inflammatory acne.
- The ALA-PDT is more effective than conventional therapy with oral antibiotics and
topical retinoids in the treatment of moderate inflammatory acne with faster action at
12 weeks of follow-up.