Recently it was demonstrated that imiquimod in addition to exerting a repairing effect in pre
malignant and malignant lesions caused by UV radiation it reverses histopathological changes
associated with the photoaging skin.
This is an experimental exploratory study. It included 17 patients. The patients were
diagnosed with photoaging grades III and IV in the scale of Glogau and volunteered to
participate in the study. Patients were treated with imiquimod 5% topically, for a time
period of 12 weeks. Biopsies were taken from periorbital skin area at baseline and after 4
weeks after completing the treatment. Adverse effects, adherence to therapy and patients'
satisfaction were measured.
Clinical and histological parameters of photoaging were studied at baseline and after
treatment. After completion of treatment with imiquimod, the final clinical evaluation was
compared to the initial one.