Overview

Photoaging Treatment With Imiquimod

Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
0
Participant gender:
All
Summary
Recently it was demonstrated that imiquimod in addition to exerting a repairing effect in pre malignant and malignant lesions caused by UV radiation it reverses histopathological changes associated with the photoaging skin. This is an experimental exploratory study. It included 17 patients. The patients were diagnosed with photoaging grades III and IV in the scale of Glogau and volunteered to participate in the study. Patients were treated with imiquimod 5% topically, for a time period of 12 weeks. Biopsies were taken from periorbital skin area at baseline and after 4 weeks after completing the treatment. Adverse effects, adherence to therapy and patients' satisfaction were measured. Clinical and histological parameters of photoaging were studied at baseline and after treatment. After completion of treatment with imiquimod, the final clinical evaluation was compared to the initial one.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
CES University
Treatments:
Imiquimod
Criteria
Inclusion Criteria:

- patients with Fitzpatrick's skin types I to IV, with a photoaging equal to or greater
than 3 on the Glogau measuring scale, who had not used systemic retinoids for over
four weeks during six months prior to baseline,

- Patients nor had they undergone chemical peels or used exfoliants or applied botulinum
toxin or any other abrasive substance on the face six months prior baseline

- patients that had not used topical retinoids or steroids two months prior to baseline

- patients that had not undergone facial rejuvenation surgery 12 months prior to
treatment.

Exclusion Criteria:

- pregnant or nursing women

- patients currently being treated with phototherapy

- patients currently being treated with photochemotherapy or whom were scheduled to
start

- patients with suspected skin cancer assessed by clinical examination

- patients with dermatological conditions with changes in the texture or color of the
skin

- Patients with inflammatory dermatoses, immunological, infectious, or neoplastic skin
diseases located in the periocular area since it could interfere with the clinical
assessment of photoaging.

- Patients that at the time of inclusion expressed treatment refusal, disinterest or
inability to comply with the protocol as well as those with skin types V and VI were
not included.