Phase III Randomized Study of Interferon Gamma in Children With Severe, Congenital Osteopetrosis
Status:
Completed
Trial end date:
2000-06-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Compare the rate of treatment failure in osteopetrosis patients receiving
interferon gamma in combination with calcitriol to the rate of treatment failure in patients
receiving calcitriol alone.
II. Compare the number of adverse events or clinical manifestations of disease progression
occurring in these patients.
III. Assess the effects of interferon gamma on hematopoiesis, cranial nerve function, and
rate of infection in these patients.