Phase II Study of Safety and Feasibility of Intensive Blood Glucose Control With Insulin on Acute Medical Wards

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with chronic obstructive pulmonary disease (COPD) are commonly admitted to hospital with exacerbations of their lung disease. A combination of the acute illness and treatment with oral steroids causes a rise in blood sugar. Patients with high blood sugar do worse than those with normal blood sugar. The aim of this study is to develop a safe and effective protocol for tight control of blood glucose with insulin on acute medical wards outside the intensive care environment. This will allow us to perform a formal trial to determine whether blood glucose control with insulin reduces death and complications from COPD exacerbations.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St George's, University of London
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Physician diagnosis of AECOPD as primary cause for admission

• Able to enter study within 24 hours of admission

Exclusion Criteria:

• Intensive care unit admission

• Moribund or not for active treatment

• Admission expected to last <48 hours

• Unable or unwilling to give informed consent

• Known Type I diabetes mellitus

• Patients with reduced awareness of hypoglycaemia including reduced Glasgow coma scale or those taking beta blockers

• Patients with renal or hepatic failure at increased risk of hypoglycaemia