Overview

Phase II Study of Peptide Receptor Radionuclide Therapy in Combination With Immunotherapy for Patients With Merkel Cell Cancer

Status:
Not yet recruiting
Trial end date:
2025-02-01
Target enrollment:
0
Participant gender:
All
Summary
The study design will be a single arm phase 2 study in patients who have progressed on immunotherapy and who are candidates to continue pembrolizumab. Prior to enrollment in the Phase II portion, a run-in study will be performed to ensure safety and tolerability of the combination of pembrolizumab and lutetium Lu 177 dotatate. Peptide receptor radionuclide therapy (PRRT) will be given every 2 months for 4 doses. Pembrolizumab will be given every 6 weeks at 400mg fixed dosing for up to 2 years, until disease progression, or unacceptable toxicity.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Pashtoon M. Kasi
Collaborators:
GI Research Foundation
Merck Sharp & Dohme LLC
Novartis
Treatments:
Lutetium Lu 177 dotatate
Pembrolizumab
Criteria
Inclusion Criteria:

1. Written informed consent and HIPAA authorization for release of personal health
information prior to registration. NOTE: HIPAA authorization may be included in the
informed consent or obtained separately.

2. Male and female, age ≥ 18 years at the time of consent.

3. ECOG Performance Status of 0-1 within 28 days prior to registration.

4. Histological or cytological evidence of Merkel cell cancer per AJCC, 8th edition.

5. Presence of somatostatin receptors by Ga-68 dotatate imaging, which is a requirement
for PRRT (lutetium Lu 177 dotatate [Lutathera®]). Must have at least one measurable
lesion per RECIST 1.1.

6. Must have progressed on treatment with an anti-PD-1/L1 mAb administered either as
monotherapy or in combination with other checkpoint inhibitors or other therapies.
PD-1 treatment progression is defined by meeting all of the following criteria:

- Has received at least 2 doses of an approved anti-PD-1/L1 mAb

- Has demonstrated disease progression after anti-PD-1/L1 as defined by RECIST
v1.1.

- Progressive disease has been documented within 12 weeks from the last dose of
anti-PD-1/L1 mAb. Note: This determination is made by the local investigator.
Once disease progression is confirmed, the initial date of disease progression
documentation will be considered the date of disease progression.

7. Prior cancer treatment must be completed and the subject must have recovered from all
reversible acute toxic effects of the regimen (other than alopecia) to Grade ≤ 1 or
baseline.

8. Demonstrate adequate organ function as defined in the table below. All screening labs
to be obtained within 28 days prior to registration.

- Hematological

- Absolute Neutrophil Count (ANC): ≥ 1500/uL

- Platelets: ≥100,000/uL

- Hemoglobin (Hgb): ≥9.0g/dL or ≥5.6mmol/L

- Renal

- Creatinine: 1.5 x ULN OR

- Measured or calculated creatinine clearance (GFR can also be used in place
of creatinine or CrCl): ≥30mL/min for participant with creatinine levels
>1.5 x institutional ULN

- Hepatic

- Total bilirubin: ≤1.5 x ULN OR direct bilirubin ≤ULN for participants with
total bilirubin levels >1.5 x ULN

- AST(SGOT) and ALT(SGPT): ≤2.5 x ULN (≤5 x ULN for participants with liver
metastases)

9. Females of childbearing potential who are sexually active with a male able to father a
child must have a negative serum pregnancy test within 7 days prior to registration.
See section 5.9 for definition of childbearing potential.

10. Females of childbearing potential who are sexually active with a male able to father a
child must be willing to abstain from heterosexual activity or to use an effective
method(s) of contraception from the time of informed consent, during the study and for
7 months after the last dose of study drug(s). Males able to father a child who are
sexually active with female of childbearing potential must be willing to abstain from
heterosexual activity or to use an effective method(s) of contraception from
initiation of treatment, during the study and for 120 days after the last dose of
study drug(s). See also section 5.9.

11. As determined by the enrolling physician or protocol designee, ability of the subject
to understand and comply with study procedures for the entire length of the study.

Exclusion Criteria:

Subjects meeting any of the criteria below may not participate in the study:

1. Has known additional malignancy that is progressing or has required active treatment
within the past 3 years. Note: Participants with basal cell carcinoma of the skin,
squamous cell carcinoma of the skin, or carcinoma in situ, excluding carcinoma in situ
of the bladder, that have undergone potentially curative therapy are not excluded.

2. Has known active CNS metastases and/or carcinomatous meningitis. Participants with
previously treated brain metastases may participate provided they are radiologically
stable, i.e. without evidence of progression for at least 4 weeks by repeat imaging
(note that the repeat imaging should be performed during study screening), clinically
stable and without requirement of steroid treatment for at least 14 days prior to
first dose of study intervention.

3. Has received a live vaccine or live-attenuated vaccine within 30 days prior to the
first dose of study drug. Administration of killed vaccines is allowed.

4. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 7 days prior to randomization.

5. Has had an allogeneic tissue/solid organ transplant.

6. Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients.

7. Has active autoimmune disease that has required systemic treatment in the past 2 years
(i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment.

8. Has a history of (non-infectious) pneumonitis that required steroids or has current
pneumonitis.

9. Has an active infection requiring systemic therapy.

10. Has a known history of Human Immunodeficiency Virus (HIV). Note: HIV testing is not
required unless mandated by local health authority.

11. Has a known history of Hepatitis B (defined as Hepatitis B surface antigen [HBsAg]
reactive) or known active Hepatitis C virus (defined as HCV RNA [qualitative] is
detected) infection. Note: Hepatitis B and Hepatitis C testing is not required unless
mandated by local health authority.

12. Has active TB (Bacillus Tuberculosis) infection.

13. Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the study, interfere with the subject's
participation for the full duration of the study, or is not in the best interest of
the subject to participate, in the opinion of the treating investigator.

14. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.

15. Is pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the study, starting with the screening visit through 7 months
(females) or 120 days (males) after the last dose of trial treatment. NOTE: breast
milk cannot be stored for future use while the mother is being treated on study.

16. Clinically significant cardiovascular disease or cardiac insufficiency (New York Heart
Association classes III-IV), cardiomyopathy, preexisting clinically significant
arrhythmia, acute myocardial infarction within 3 months of enrollment, angina pectoris
within 3 months of enrollment.