Phase II Study of Lactulose and Circadian Rhythms in Patients With Cirrhosis
Status:
Completed
Trial end date:
1997-02-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Assess the effect of lactulose on the circadian rhythm of plasma melatonin in
patients with subclinical hepatic encephalopathy.
II. Assess the intrasubject variability of circadian melatonin levels and neuropsychological
tests.
III. Assess which elements of the neuropsychological test battery show the response to
lactulose.