Phase II Study of Hemay005 in Patients With Active Ankylosing Spondylitis
Status:
Not yet recruiting
Trial end date:
2023-12-23
Target enrollment:
Participant gender:
Summary
This study is a multicenter, randomized, double-blind, placebo-controlled phase II clinical
study. The study was divided into three stages, including screening period, treatment period
and observation period. All subjects need to enter a 28 day (4-week) observation period after
stopping hemay005 treatment.
Screening period: all subjects shall have a screening period of no more than 28 days (4
weeks) before the baseline visit (day 1 of randomization).
Treatment period: after screening and meeting the inclusion requirements of the study, as
subjects were randomly divided into hemay005 60 mg twice daily (bid) dose group (group A), 75
mg bid dose group (group B) and placebo control group (Group C) according to the ratio of
1:1:1. A total of 90 subjects were included in the three groups. They were titrated in the
first 6 days. From the 7th day, the subjects received fixed dose administration twice a day
for 112 consecutive days (16 weeks). Considering the difference in the proportion of men and
women with as, and the slow onset and mild condition of women, randomization will minimize
the imbalance between treatment groups according to gender stratification.
Observation period: Subjects in the study (including those who withdrew from the treatment
early for any reason) shall be observed for 4 weeks after the end of the last administration.
Main purpose:
The efficacy of hemay005 tablet in the treatment of active ankylosing spondylitis (as) was
evaluated by placebo parallel control.
Secondary purpose:
- To evaluate the safety of oral hemay005 tablets in patients with active as.
- To evaluate the population pharmacokinetics of hemay005 tablets in patients with active
as.