Phase II Study of Dasatinib (BMS-354825) for Androgen-deprived Progressive Prostate Cancer

• Status: Completed
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to learn if men with metastatic prostate cancer and rising Prostate Specific Antigen (PSA), who have been surgically castrated or are undergoing androgen deprivation with Luteinizing Hormone Releasing Hormone (LHRH) treatment, respond to dasatinib. The safety of this treatment will also be studied.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bristol-Myers Squibb
• Treatments: Androgens; Dasatinib

Criteria

Inclusion Criteria:

• males, 18 or older

• proven advanced prostate cancer

• documented metastatic disease

• rising PSA levels

• castrate levels of testosterone

Exclusion Criteria:

• symptomatic CNS (brain or spinal cord) metastasis

• medical condition which may increase the risk of toxicity

• any prior or ongoing anti-cancer medical therapy or immunotherapy for prostate cancer other than primary androgen deprivation agents

• unable to take oral medication