Phase II Study Evaluating the Safety and Efficacy of GSK315234A in Patients With Rheumatoid Arthritis
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
This is a randomized, double-blinded, placebo-controlled adaptive, dose finding study to
investigate the safety, tolerability, PK, PD and efficacy of single and repeat intravenous
infusions of GSK315243A in patients with active rheumatoid arthritis. The study is divided
into 2 parts: Part A is an adaptive, dose finding phase which will provide safety,
tolerability, PK and PD on single intravenous infusions. Part B is a repeat dose phase which
will provide safety, tolerability, PK, PD and efficacy following repeat intravenous infusions
of a selected dose level.