Overview

Phase II Short-term Adjuvant Therapy and Biomarker Studies With Targeted Agents in Women With Estrogen Receptor Negative Breast Cancer

Status:
Active, not recruiting
Trial end date:
2022-01-01
Target enrollment:
0
Participant gender:
Female
Summary
The goal of this clinical research study is to learn if dasatinib can help prevent breast cancer from developing in the unaffected breast. Dasatinib is designed to decrease the activity of one or more proteins that are responsible for the uncontrolled growth of tumor cells. This is an investigational study. Dasatinib is FDA approved and commercially available for the treatment of leukemia. Its use in breast cancer patients in investigational. Up to 66 patients will take part in this multicenter study. Up to 60 will be enrolled at MD Anderson.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborators:
Bristol-Myers Squibb
Susan G. Komen Breast Cancer Foundation
Treatments:
Dasatinib
Estrogens
Criteria
Inclusion Criteria:

1. Histological confirmation of ER negative breast carcinoma (defined as less than 10%),
stage I, II, or III

2. Completed all adjuvant therapy including (if indicated) endocrine, trastuzumab,
radiation therapy

3. At least 18 years of age.

4. Female: A female is eligible to enter and participate in the study if she is of: a.
Non-childbearing potential (i.e., women with functioning ovaries who have a current
documented tubal ligation, hysterectomy alone, hysterectomy and bilateral
salpingo-oophorectomy, bilateral salpingo-oophorectomy alone or women who are
post-menopausal); or b. Childbearing potential (i.e., women with functioning ovaries
and no documented impairment of oviductal or uterine function that would cause
sterility. This category includes women with oligomenorrhoea (severe), women who are
perimenopausal, and young women who have begun to menstruate), has a negative serum
pregnancy test at screening, and agrees to one of the following where considered
acceptable to the local IRB/IEC: • Double-barrier contraception (condom with
spermicidal jelly, foam suppository, or film; diaphragm with spermicide; or male
condom and diaphragm).

5. (Continued from above) • Abstinence from sexual intercourse from 2 weeks prior to
administration of the investigational product, throughout the active study treatment
period. • Male partner who is sterile prior to the female subject's entry into the
study and is the sole sexual partner for that female subject. • Any intrauterine
device (IUD). • Barrier methods including diaphragm or condom with a spermicide.

6. Able to swallow and retain oral medication.

7. ECOG (Eastern Cooperative Oncology Group) performance status 0 to 2.

8. Provided written informed consent.

9. Adequate bone marrow function: Hemoglobin >/= 9 gm/dL. • Absolute granulocyte count
>/= 1,500/mm^3 (1.5 x 10^9/L). • Platelets >/= 75,000/mm^3 (100 x 10^9/L).

10. Serum creatinine < 1.4 mg/dL or calculated creatinine clearance (CrCl) >/= 30 mL/min

11. Total bilirubin
12. Aspartate and alanine transaminase (AST or ALT) reference range.

13. Patients must have a baseline ECG with QTcF within the normal range within 28 days
prior to registration.

14. Normal mammogram of unaffected breast within 12 months prior to study entry.

Exclusion Criteria:

1. Unwillingness to undergo RPFNA.

2. Contraindication to RPFNA including breast implant(s), bilateral radiation,
anticoagulation (excluding those on 81mg aspirin).

3. Concurrent medical condition that would increase drug toxicity: Pleural or pericardial
effusion, coagulation or platelet function disorder, ongoing or recent (less than 3
months gastrointestinal bleeding)

4. Uncontrolled angina, congestive heart failure, MI (within last 6 months), congenital
long QT syndrome, history of clinically significant ventricular arrhythmia, prolonged
QTcF interval on pre-entry EKG (greater than normal range)

5. Hypokalemia or hypomagnesemia if it cannot be corrected

6. Is a pregnant or lactating female.

7. Has evidence of recurrent or metastatic (Stage IV) breast cancer.

8. Is considered medically unfit for the study by the investigator as a result of the
medical interview, physical exam, or screening investigations.

9. Has a known immediate or delayed hypersensitivity reaction or idiosyncrasy to
dasatinib

10. Has received treatment with any investigational drug in the previous 4 weeks.

11. Has received chemotherapy, immunotherapy, biologic therapy or endocrine therapy within
the past 12 weeks.

12. Is currently receiving oral steroid treatment (inhaled steroids are permitted)

13. Oral estrogen, progesterone, testosterone therapy within last 3 months.

14. Concomitant Medications: Drugs that are considered category D (Consider therapy
modification) and X (Avoid combination) using the Lexicomp database are prohibited.
Concomitant drugs that fall into categories A (No known interaction), B (no action
needed) and C (monitor therapy) are allowed.