Phase II Randomized Study of the Effects of Growth Hormone on Children and Adolescents on Maintenance Dialysis
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
OBJECTIVES: I. Evaluate the separate and combined skeletal effects of recombinant human
growth hormone (GH) and calcitriol in patients with adynamic renal osteodystrophy.
II. Assess whether calcium-regulated changes in parathyroid hormone secretion predict changes
in bone formation.
III. Characterize the response to GH in cancellous bone and in growth plate cartilage in
patients with secondary hyperparathyroidism during calcitriol therapy.
Phase:
Phase 2
Details
Lead Sponsor:
National Center for Research Resources (NCRR)
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) University of California, Los Angeles