Phase II Randomized Placebo-controlled Study With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Randomized placebo-controlled study with vitamine K2 (Menaquinone-4) in calcified carotid stenosis. We evaluate the plaque remodelling after administration of vitamine, reducing the calcified component.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Azienda Ospedaliera Sant'Anna
• Treatments: Vitamin K; Vitamin K 2; Vitamin MK 7; Vitamins

Criteria

Inclusion Criteria:

• carotid stenosis between 50 and 70% (NASCET criteria) with calcified plaque

Exclusion Criteria:

• renal and/or hepatic failure

• diseases with secondary calcifications

• dementia

• previous strokes

• concomitant use of anticoagulants

• concomitant infections

• pregnancy or breastfeeding

• reduced patient's compliance