Overview

Phase II Pantiumumab-IRDye800 in Head & Neck Cancer

Status:
Recruiting
Trial end date:
2027-12-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine if panitumumab-IRDye800 is effective in identifying cancer, compared to surrounding normal tissue, and the further characterize the safety profile of this drug.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Alabama at Birmingham
Treatments:
Panitumumab
Criteria
Inclusion Criteria:

1. Biopsy confirmed diagnosis of squamous cell carcinoma of the head and neck

2. Diagnosis of any T stage, any subsite within the head and neck that are scheduled to
undergo surgical resection. Patients with recurrent disease or a new primary will be
allowed.

3. Planned standard of care surgery with curative intent for squamous cell carcinoma

4. Male or female patients age ≥ 18 years

5. Have life expectancy of more than 12 weeks

6. Karnofsky performance status of at least 70% or ECOG/Zubrod level 1

7. Have acceptable hematologic status, coagulation status, kidney function, and liver
function including the following clinical results:

1. Hemoglobin ≥ 9 gm/dL

2. Absolute Neutrophil Count ≥ 1500

3. White Blood Cell count > 3000/mm3

4. Platelet count ≥ 100,000/mm3

5. Serum creatinine ≤ 1.5 times upper reference range

Exclusion Criteria:

1. Received an investigational drug within 30 days prior to first dose of
panitumumab-IRDye800

2. Had within 6 months prior to enrollment: MI, CVA, or uncontrolled CHF

3. History of infusion reactions to any monoclonal antibody therapies

4. Women who are pregnant or breast-feeding

5. Evidence of QT prolongation on pretreatment ECG (greater than 440 ms in males or
greater than 450 ms in females)

6. Magnesium or potassium lower than the normal institutional values

7. Patients receiving Class IA (quinidine, procanamide) or Class III (dofetilide,
amiodarone, sotalol) antiarrhythmic agents

8. Patients with a history or evidence of interstitial pneumonitis or pulmonary fibrosis

9. TSH > 13 micro International Units/mL