Phase I Study of Disulfiram and Copper Gluconate for the Treatment of Refractory Solid Tumors Involving the Liver
Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
OBJECTIVES:
Primary Objectives
• Determine the safety and toxicity profile of co-administration of disulfiram and copper
gluconate for the treatment of refractory malignancies that have metastasized to the liver.
Secondary Objectives
- Determine if disulfiram and copper gluconate induce measurable responses for the
treatment of hepatic metastases from solid tumors.
- Qualitative assessment of the induction of S-glutathionylation in proteins of
circulating leukocytes in patients treated with disulfiram and copper gluconate.