Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT
Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
Primary Objective:
1. To determine efficacy of escalating doses of pentostatin in combination with tacrolimus
and methotrexate for the prevention of acute graft-versus-host disease (GVHD) in the context
of unrelated donor and one antigen mismatched related donor transplantation.
Secondary Objectives:
1. To determine safety of escalating doses of pentostatin in combination with tacrolimus
and methotrexate.
2. To reduce the incidence of acute GVHD following transplants with unrelated donor to 40%.
3. To document blood levels of tacrolimus when combined with pentostatin.