Overview

Phase I, Dose Escalation Study of Decitabine

Status:
Completed
Trial end date:
2018-09-18
Target enrollment:
Participant gender:
Summary
Decitabine is a hypomethylating agent that has shown significant anti-leukemic effect in Myelodysplastic Syndrome (MDS) and Acute Myeloblastic Leukemia (AML). This study is based on the hypothesis that Decitabine delivered after allo-hematopoietic stem cell transplant (HSCT) in patients with leukemia will enhance disease control by the allogeneic immune system and lead to a longer disease free survival. The study is designed to provide safety data of low-dosing in the post-transplant setting.
Phase:
Phase 1
Details
Lead Sponsor:
University of Florida
Collaborator:
Hyundai Hope On Wheels
Treatments:
Azacitidine
Decitabine