Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a body weight adjusted dose of thyroxin is superior to treatment guided by laboratory results of thyroxin hormones in patients with central hypothyroidism. Moreover beneficial effects of triiodthyronine supplementation are investigated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Freiburg

Criteria

Inclusion Criteria:

• hypopituitarism of at least 3 axes (TSH plus gonadotropin, somatotropin, corticotropin or ADH deficiency)

• termination of surgical or radiation treatment of pituitary tumors at least six month before study entry

• BMI of 20 - 39.9 kg/m2

• non-smoking status.

Exclusion Criteria:

• history of cardiovascular or pulmonary diseases

• current thyroxin dosage > 1.6 µg/kg bw

• pregnancy

• epilepsy

• cerebrovascular diseases

• nodular goiter