Non-alcoholic steatohepatitis, abbreviated as NASH, is a chronic liver disease that may
progress to cirrhosis. The disease is mostly associated with obesity and type 2 diabetes
mellitus, or insulin resistance and is very common. However, Treatment of NASH is a
significant unmet clinical need.
IVA337 (lanifibranor) is a next generation pan-PPAR (peroxisome proliferator-activated
receptors) agonist addressing the pathophysiology of NASH : metabolic, inflammatory and
fibrotic.
The purpose of this research is to evaluate the efficacy and the safety of two doses of
IVA337 (800mg, 1200 mg) per day for 24 weeks versus placebo in adult NASH patients with liver
steatosis and moderate to severe necroinflammation without cirrhosis.