Overview

Phase 1a Study in Healthy Smokers to Investigate the Effect With MMI-0100 on Airway Inflammation in Induced Sputum After Challenge With Inhaled Lipopolysaccharide

Status:
Unknown status
Trial end date:
2017-06-01
Target enrollment:
0
Participant gender:
All
Summary
A Phase 1a, randomized, placebo controlled, two-way crossover study is to determine the effect of inhaled MMI-0100 compared to placebo following LPS challenge on inflammatory markers.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Moerae Matrix, Inc.
Criteria
Inclusion Criteria:

- Written signed informed consent

- Comply with study procedures

- Body mass index (BMI) between 18 and 35 kg/m2 inclusive;minimum body weight of 50 kg

- Male subjects:

1. Subjects with female partners of childbearing potential must agree to use a
highly effective form of birth control, which entails the use of oral, injected
or hormonal methods of contraception or intrauterine device/system by the female
partner, in combination with a barrier method (e.g. condom, diaphragm, cervical
cap with spermicide) during the study and for 3 months after discontinuation of
treatment

2. Subjects who are sterilised or have a female partner who is sterilised

3. Subjects with a lifestyle that implies abstinence from sexual activity during the
study and for 3 months after discontinuation of treatment

- Female subjects:

1. Confirmed post-menopausal women (no periods for at least one year and follicle
stimulating hormone (FSH) levels compliant with post-menopausal status according
to reference values)

2. Subjects agreeing to use highly effective form of birth control, which entails
the use of oral, injected or implanted hormonal methods of contraception or
intrauterine device/system in combination with a barrier method (e.g. condom,
diaphragm, cervical cap with spermicide) during the study and for 3 months after
discontinuation of treatment

3. For females of childbearing potential: females must have a negative urine
pregnancy test at screening and admission

- Normal physical examination, laboratory values, 12-lead electrocardiogram (ECG) and
vital signs

- Be current smokers with defined smoking history of ≥10 pack years

- Ability to perform reproducible spirometry

- Demonstrate an FEV1 ≥80% of their predicted normal

- Demonstrate no evidence of airway obstruction

- Normal airway responsiveness to inhaled methacholine

- Have negative screens for serum hepatitis B surface antigen, Hepatitis C antigen and
human immunodeficiency virus (HIV)

- Be able to produce a minimum of 0.1g sputum after induction with inhaled hypertonic
saline at Visit 0

Exclusion Criteria:

- Subjects with an uncontrolled cardiovascular, respiratory, haematologic, immunologic,
renal, neurologic, hepatic, endocrine disease, or any condition that might, in the
judgment of the Investigator, place the subject at undue risk or potentially
compromise the results or interpretation of the study

- Any clinically relevant abnormal value or physical finding that may interfere with the
interpretation of the study results or constitute a health risk for the subject if
he/she takes part in the study

- Symptoms, signs or laboratory findings suggestive of an ongoing infective illness at
the time of enrolment

- A history of respiratory disease including asthma

- Donation of more than 1200 mL of blood within 12 months of Visit 0 or, donation of
blood in total >500 mL within 3 months prior to Visit 0

- Symptoms of any clinically significant illness within 2 weeks pior to Visit 0

- A significant history of alcohol abuse or consumption of more than 28 units (male) or
21 units (female) of alcohol per week

- A significant history of drug abuse (including benzodiazepines) or positive urine
drugs of abuse test