Overview
Phase 1a/1b Study of STK-012 Monotherapy and in Combination With Pembrolizumab in Subjects With Solid Tumors
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2026-03-01
2026-03-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
This is a first-in-human, phase 1a/1b, multicenter, open-label, dose escalation study of STK-012 as monotherapy and in combination with pembrolizumab in patients with selected advanced solid tumors.Phase:
Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
SynthekineTreatments:
Pembrolizumab
Criteria
Selected Inclusion Criteria1. In dose-escalation (Phase 1a), patients must have selected tumor types and must have
progressed after standard of care treatment, or be intolerant to treatment, or refused
standard treatment
2. Available archived tumor tissue sample. In the setting where archival material is
unavailable or unsuitable for use, the patient must consent and undergo fresh tumor
biopsy. In some patients, a new pre-treatment and on-treatment tumor biopsy may be
required.
3. Patients with central nervous system (CNS) metastases must have been treated and be
asymptomatic.
Selected Exclusion Criteria:
1. Received systemic anti-cancer therapy within 3 weeks of the first dose of study
treatment or small molecule kinase inhibitors within 6 elimination half-lives of the
first dose of study treatment.
2. Received definitive radiotherapy within 2 weeks of the first dose of study treatment;
or palliative radiotherapy (< 2 weeks of radiotherapy to non-central nervous system
[CNS] disease) within 1 week of the first dose of study treatment.
3. Received prior IL-2-based or IL-15-based cytokine therapy