Overview

Phase 1 Study of the Pharmacokinetics of High Dose Amoxicillin With and Without Probenecid in Pregnant Women

Status:
Not yet recruiting

Trial end date:
2023-07-01

Target enrollment:

Participant gender:

Summary

This phase I pharmacokinetic study compares four medication regimens (high or low dose amoxicillin +/- probenecid) in 40 healthy pregnant women at the time of delivery. The goal of the study is to assess medication safety and efficacy as measured by the attainment of therapeutic levels in maternal serum and amniotic fluid. This information will be used to identify a dosing regimen that is expected to reach therapeutic levels in maternal and fetal compartments. In future trials, effective dosing strategies identified can be tested in women with syphilis in pregnancy.

Phase:

Phase 1

Details

Lead Sponsor:

University of Alabama at Birmingham

Treatments:

Amoxicillin
Probenecid