Overview

Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine

Status:
Recruiting
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
A 6-cohort single ascending dose (SAD) study will be conducted in healthy volunteers utilizing a slow-infusion intravenous (IV) route of administration. Standard safety, pharmacokinetics (PK) and qEEG monitoring will be evaluated at all dose levels. Subsequently, a 3-cohort multiple ascending dose (MAD) study will be conducted. Doses will be administered on days 1, 4, 7, and 10. Standard safety parameters will be monitored, and PK will be evaluated at all dose levels.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Mental Health (NIMH)