This study is a methodology study to evaluate a microdose strategy for Drug-Drug Interaction
(DDI) which will be useful in the evaluation of the backup compounds for GSK706769, as well
as possibly other assets. The safety, tolerability and pharmacokinetics will be evaluated in
healthy adult subjects. This will be an open-label fixed-sequence 2-period study in healthy
male volunteers after oral administration of [14C]-GSK706769 alone and in the presence of
Ketoconazole.