Overview

Pharmacological Treatment In Osteoarthritis

Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine the efficacy of hydroxychloroquine in hand osteoarthritis.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Maasstad Hospital
Treatments:
Hydroxychloroquine
Criteria
Inclusion Criteria:

- Age ≥ 40 years

- Primary hand OA according to the ACR classification

- Heberden or Bouchard nodule or Kellgren-Lawrence grade 1, 2 or 3 changes in ≥ 2
symptomatic joints

- Pain in the dominant hand ≥ 12 months

- Use of an NSAID for ≥ 1 episode of pain

- Written informed consent

Exclusion Criteria:

- Secondary hand OA, e.g. haemochromatoses, rheumatoid arthritis, posttraumatic

- Kellgren-Lawrence grade 4 OA

- Use of hydroxychloroquine within 3 months before entering the study

- Use of NSAIDs or corticosteroids within 7 days before entering the study

- Retinopathy

- Myasthenia gravis

- Known allergy or hypersensitivity for hydroxychloroquine