Pharmacological Management of Seizures Post Traumatic Brain Injury
Status:
Not yet recruiting
Trial end date:
2028-03-01
Target enrollment:
Participant gender:
Summary
The overall aim of the MAST trial is to define best practice in the use of anti-epileptic
drugs (AEDs) for patients following a traumatic brain injury (TBI). The trial will consist of
two parts. The first part aims to answer whether a shorter or a longer course of AEDs is
better to prevent further seizures in patients who have started having seizures following TBI
(MAST - duration). The second part aims to answer whether a 7-day course of either Phenytoin
or Levetiracetam should be used for patients with a serious TBI to prevent seizures from
starting (MAST- prophylaxis).
Phase:
Phase 3
Details
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust