Overview

Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity

Status:
Completed
Trial end date:
2008-11-01
Target enrollment:
0
Participant gender:
All
Summary
The present study on pharmacological intervention in autonomic nervous dysregulation(parasympathetic dysfunction,) regarding insulin resistance, is a concept testing in humans tohelp identify potential new pharmacological target sites in the central nervous system.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
AstraZeneca
Treatments:
Atropine
Physostigmine
Criteria
Inclusion Criteria:

- Signed written informed consent

- BMI of lean and abdominally obese men and women

- weight stable

Exclusion Criteria:

- Ongoing clinically significant diseases

- History of repeated syncope

- resting pulse<50 or systolic blood pressure <100