Pharmacological Comparison of Continuous and Intermittent Infusions of Cloxacillin
Status:
Completed
Trial end date:
2018-09-18
Target enrollment:
Participant gender:
Summary
Our objective is to establish pharmacological equivalence of intermittent and continuous
infusion of cloxacillin during methicillin-susceptible Staphylococcus aureus (MSSA) bone and
joint infections (BJI). Twelve patients suffering MSSA BJI will receive both administration
modalities and serum concentrations of cloxacillin will be determined after 3 days of II and
3 days of continuous infusion in a prospective, randomized, open-label, monocentric crossover
study design.