Pharmacological Agents for Chronic Spinal Cord Injury (SCI)
Status:
Recruiting
Trial end date:
2024-07-30
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the short-term effects of 3 approved FDA drugs
(cyproheptadine (CPH), carbidopa-levodopa (CD-LD), and atomoxetine (ATX)) on motor responses
when delivered in combination with hand training exercises in people with chronic spinal cord
injury. The goal is to learn how to better strengthen connections between the brain and
spinal cord after spinal cord injury, and if this connection is improved by one(or more) of
the drugs. Multiple aspects of nerve transmission and muscle response will be measured via
noninvasive brain and spinal cord stimulation, along with motor performance (dexterity and
strength).