Pharmacokinetics of Valacyclovir Oral Solution in Children
Status:
Terminated
Trial end date:
2021-05-12
Target enrollment:
Participant gender:
Summary
Valacyclovir has replaced acyclovir in many clinical scenarios. Pharmacokinetic data support
the use of oral valacyclovir in children, but practical problems exist in children having to
take adult-dose tablets. A formulation with acceptable palatability, good pharmaceutical
quality and possibility of flexible dosing is developed. Pharmacokinetic data of this
formulation is missing.
The present study investigates the pharmacokinetics of valacyclovir oral solution in children
by determine the area under the curve (AUC0-12), time above critical concentration (Ccrit),
Cmax and Tmax of acyclovir.
Secondary, the safety profile of a single dose of valacyclovir oral solution will be
determined.