Pharmacokinetics of Oseltamivir in Newborns and Infants
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
Oseltamivir dosing in infants < 3 months of age is based on a single pharmacokinetic study in
20 infants from a single center. This dataset is limited by a lack of robustness, because
only 1 sample was collected from each participant. The investigators obtained two blood
samples each from infants receiving oseltamivir after obtaining informed consent from the
infant's parents. The investigators propose to analyze the blood samples to determine the
amount of oseltamivir in the infant's blood. Measurement of these values will increase the
understanding of the absorption and elimination of oseltamivir in preterm and term infants,
and improve our ability to provide the correct doses to this high risk population.
Details
Lead Sponsor:
St. Louis Children's Hospital
Collaborators:
Genentech, Inc. Washington University School of Medicine