Pharmacokinetics of Oral Morphine and Pharmacogenomics of CYP2D6 and UGT2B7, in an Urban Pediatric Population Presenting for Elective Surgery

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to identify and collect samples from children who have taken a single oral dose of the pain medication morphine, and to determine the genetic differences in the way children metabolize (break down in the body and how it affects them) morphine.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of British Columbia
• Treatments: Morphine

Criteria

Inclusion Criteria:

• 2 - 6 years of age

• ASA 1 & 2 elective surgical patients - Procedures requiring opioid analgesia - Minimal hospital stay of 4 hrs

• Informed consent

Exclusion Criteria:

• Allergy or adverse reaction to morphine

• Contraindication to morphine analgesia, such as a potential difficult airway -- Abnormal hepatic or renal function known by history or available laboratory results

• Current regular opioid use

• Surgical or anesthetic contraindication to oral premedication such as gastro-esophageal reflux disease

• Children with a BMI of <10'ile or >90'ile

• Declines study participation