The objective of this study is to test the effect of a range of doses of a novel nicotine
film on plasma nicotine levels, expired carbon monoxide and, via a questionnaire, subjective
ratings of the film and side effects. The nicotine film is not part of standard of care and
is not available in a non-investigational setting. The investigators hypothesize that plasma
nicotine levels will be in keeping with those induced by other oral nicotine replacement
therapies (NRTs) and by the smoking of a cigarette. Thus, the investigators predict that
random delivery of nicotine via the oral film will be safe and well-tolerated by the human
subjects.