Pharmacokinetics of Levofloxacin in Intensive Care Unit

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is 1. to describe levofloxacin pharmacokinetics in ICU patients suffering from pneumonia with taking into account physio-pathological parameters. 2. to verify clinical and bacteriological efficiency and to know if the peak/Minimum Inhibitory Concentration (MIC) ratio > 5 and Area Under Curve (AUC) /Minimum Inhibitory Concentration(MIC) ratio > 125. No therapeutic drug monitoring will be performed in this study.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Toulouse
• Treatments: Levofloxacin; Ofloxacin

Criteria

Inclusion Criteria:

• severe community-acquired pneumonia due to a strain sensible to levofloxacin

• Age > 18 years

• Informed consent

• SAPS II (simplified acute physiological score) > 20 Awaited duration of survival higher than 7 days

Exclusion Criteria:

• Historic of allergy to levofloxacin

• Resistant strain to levofloxacin

• Pregnancy

• Contra-indications of levofloxacin use, renal failure