Pharmacokinetics of Fluconazole IV as Prophylaxis or Therapy to ICU Patients
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
The pharmacokinetics of fluconazole are expected to be different in ICU patients compared to
non-ICU patients. The investigators will determine fluconazole and free fluconazole
concentrations in 20 ICU patients, who will get intravenous fluconazole as standard care.
Switching to oral/enteral fluconazol is allowed after day 3.
A full pharmacokinetic curve will be taken on day 3 of iv therapy and limited pharmacokinetic
curves on day 7 of iv therapy and/or on day 3 of oral therapy; trough levels will be taken
daily after intravenous therapy.