Pharmacokinetics of Antiepileptics in Patients on CRRT

• Status: Completed
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to characterize drug pharmacokinetics and optimize dosing strategies in patients on CRRT.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Maryland; University of Maryland, Baltimore
• Collaborator: Center for Translational Medicine (CTM), University of Maryland School of Pharmacy
• Treatments: Anticonvulsants; Etiracetam; Ketamine; Lacosamide; Levetiracetam; Phenobarbital; Phenytoin; Valproic Acid

Criteria

Inclusion Criteria:

• Expected to be on CRRT and receive any of the following for more than 24 hrs

• Expected to survive for more than 24 hrs

• Achievement of steady state drug concentrations prior to study enrollment

Exclusion Criteria:

• Pregnancy

• Age < 18

• Prisoner