Overview

Pharmacokinetics and Pharmacodynamics of the Gametocytocidal and Post-treatment Chemoprotective Effects of Antimalarials

Status:
Active, not recruiting

Trial end date:
2021-04-01

Target enrollment:

Participant gender:

Summary

Single-center phase II/III clinical investigation of the pharmacokinetics and pharmacodynamics of artemether-lumefantrine and dihydroartemisinin-piperaquine for gametocyte clearance and post-treatment chemoprotection in Zambian children with uncomplicated falciparum malaria.

Phase:

Phase 2/Phase 3

Details

Lead Sponsor:

Johns Hopkins Bloomberg School of Public Health

Collaborator:

Tropical Diseases Research Centre

Treatments:

Artemether
Artemether, Lumefantrine Drug Combination
Artemisinins
Artenimol
Dihydroartemisinin
Lumefantrine
Piperaquine