Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System

• Status: Unknown status
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To explore and compare the effects of propoful, sevoflurane, and a combination of both on the pharmacokinetics and pharmacodynamics of rocuronium.

To discover and confirm sex differences on the pharmacokinetics and pharmacodynamics of rocuronium.

To evaluate and examine aged people on the pharmacokinetics and pharmacodynamics of rocuronium.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tianjin Medical University General Hospital
• Treatments: Anesthetics; Propofol; Rocuronium; Sevoflurane

Criteria

Inclusion Criteria:

• ASA physical status group I and II

• elective surgical procedures

• The subject has given written informed consent to participate

Exclusion Criteria:

• Coronary heart disease, bronchial asthma, cardiac, lung, hepatic and renal insufficiency

• Severe HBP, obesity (BMI>30)

• Neuromuscular and metabolic diseases

• Receiving medication known to influence neuromuscular transmission

• Pregnancy, psychiatric disease

• Allergy history

• Inability to understand the Study Information Sheet and provide a written consent to take part in the study.