Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration
Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
The objectives of the study are
- to evaluate pharmacokinetics, distribution in blood leucocytes, metabolism and
methemoglobinemia after single-dose and repeated-dose administration of 100 mg of
dapsone in healthy subjects genotyped for CYP2C9 and NAT2
- to evaluate serum through levels, distribution in blood leucocytes and methemoglobinemia
after repeated-dose treatment with dapsone in patients with autoimmune bullous
dermatoses before and after concomitant treatment with glucocorticoids