Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
This study will be performed to determine the safety, tolerability, and dose-response to
inorganic nitrate on exercise capacity in HFpEF. There are two primary goals for this study:
1. Determine the population-specific pharmacokinetics and dose of KNO3 that can be safely
given to subjects with HFpEF.
2. Determine if there is a dose-response effect of nitrate supplementation on exercise
capacity, evidenced by peak oxygen consumption (peak VO2), and physiologic adaptations
to exercise.