Overview

Pharmacokinetics (PK) of 20 mg Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy Participants

Status:
Completed
Trial end date:
2007-08-23
Target enrollment:
0
Participant gender:
All
Summary
This is a study to compare the pharmacokinetic profile of teduglutide in healthy participants with normal hepatic function with participants who have moderate hepatic impairment.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
NPS Pharma
Shire
Treatments:
Teduglutide
Criteria
Inclusion Criteria:

- Adult male or female between 18 and 85 years of age

- BMI of 18 to 40, inclusive

- Creatinine clearance (greater) > 50 milliliter per minute(mL/min)

- Able to understand and willing to sign an informed consent form (ICF)

- Willing and able to be confined at the study site for approximately 2.5 days

- Female participants who are postmenopausal, surgically sterilized, or women of
childbearing potential (WOCBP) using an effective form of birth control during the
study

- WOCBP must have a negative urine beta human chorionic gonadotropin (β-hCG) result at
screening (Days -28 to -2) and check-in (Day -1)

- Negative urine test for selected drugs of abuse and alcohol at screening and check-in
(Day-1)

Inclusion for participants with Impaired Hepatic Function (in addition to above criteria):

- Documented moderately impaired hepatic function defined by a total score of 7 to 9 on
the Child-Pugh Classification at screening and check-in

- No clinically significant change in disease status within the 3 months prior to study
entry

- Abnormal laboratory results that are related to the participants underlying condition
clinically stable as deemed by the investigator

- Abstained from alcohol use within 90 days prior to study entry when hepatic impairment
is known to be secondary to alcohol abuse

- On medication and/or treatment regimen if, in the opinion of the investigator, the
underlying disease is under control

- Participants with normal hepatic function will be matched collectively as a group by
gender, age, and BMI with the participants with moderately impaired hepatic function.
Participants with normal hepatic function will also be matched on an individually with
the participants with moderately impaired hepatic function with regard to renal
function In addition to inclusion criteria # 1 to 8, participants with normal hepatic
function must also meet the following inclusion criteria to be eligible for
participation in this study:

- Similar level of renal function based on Cockroft-Gault equation as the matched
participant with moderately impaired hepatic function

- Medically healthy with normal or clinically insignificant clinical results at
screening and check-in

Exclusion Criteria:

- Donated 1 pint or more of blood or blood products within 7 days prior to the study,
and/or had a blood or plasma donation within 7 days prior to the study

- Participated in any other investigational drug trial within 30 days prior to study
entry

- Have a hemoglobin level < 10.0 g/dL at screening (Days -28 to -2)

- Have any condition that, in the opinion of the investigator or sponsor, would make
them unsuitable for the study

- Participants with Impaired Hepatic Function (in addition to exclusion criteria 1-4):

- Acceptable Child-Pugh score (Grade B, score of 7 to 9), which is associated with
conditions such as metastatic cancer rather than impaired hepatic function

- Participants with Normal Hepatic Function (in addition to exclusion criteria 1-4

- History or presence of clinically significant cardiovascular, pulmonary, hepatic,
renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic,
neurologic, or psychiatric disease

- History or evidence of congenital nonhemolytic hyperbilirubinemia

- History or evidence of gallstone disease or stomach or intestinal surgery, with the
exception of appendectomy

- History or evidence of colorectal cancer

- History or evidence of malabsorption, pancreatic disease or gastrointestinal
disorders, such as irritable bowel syndrome, Crohn's disease or ulcerative colitis

- Taking prescription or over-the-counter medication (with the exception of daily low
dose aspirin regimen and/or birth control)during the 7 days preceding confinement to
the clinical research unit, and/or who anticipate a need to use prescription or
over-the-counter medication during the study