Pharmacokinetics, Metabolism and Analgesic Effects of Flupirtine
Status:
Completed
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
Flupirtine is metabolized in-vitro via carbamate cleavage and N acetylation to glucuronides
and mercapturic acid derivatives. The formation of reactive, toxic intermediate products may
be influenced by genetic polymorphisms of the involved conjugative metabolic pathways. So the
purpose of this study is to measure pharmacokinetics, metabolism and analgesic effects of
flupirtine in dependence on the function of NAT2, UGT1A1 and GSTP1.