Pharmacokinetic of Tacrolimus in Paediatric Liver Transplant Patients
Status:
Recruiting
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
Tacrolimus is the cornerstone immunosuppressant in children with liver transplantation, its
use is complicated by its narrow therapeutic index and variable pharmacokinetics. This study
is designed to assess the posology of tacrolimus in post-transplantation in the month after
liver transplantation to obtain a therapeutic target between 10-15 ng/mL and the impact of
biological and genetic factors on the pharmacokinetic parameters in paediatric liver
transplant recipients.